In Vitro Antiplasmodial and Cytotoxic Activities of Compounds from the Roots of Eriosema montanum Baker f. (Fabaceae)

Malaria remains one of the leading causes of death in sub-Saharan Africa, ranked in the top three infectious diseases in the world. Plants of the Eriosema genus have been reported to be used for the treatment of this disease, but scientific evidence is still missing for some of them. In the present study, the in vitro antiplasmodial activity of the crude extract and compounds from Eriosema montanum Baker f. roots were tested against the 3D7 strain of Plasmodium falciparum and revealed using the SYBR Green, a DNA intercalating compound. The cytotoxicity effect of the compounds on a human cancer cell line (THP-1) was assessed to determine their selectivity index. It was found that the crude extract of the plant displayed a significant antiplasmodial activity with an IC₅₀ (µg/mL) = 17.68 ± 4.030 and a cytotoxic activity with a CC₅₀ (µg/mL) = 101.5 ± 12.6, corresponding to a selective antiplasmodial activity of 5.7. Bioactivity-guided isolation of the major compounds of the roots’ crude extract afforded seven compounds, including genistein, genistin and eucomic acid. Under our experimental conditions, using Artemisinin as a positive control, eucomic acid showed the best inhibitory activity against the P. falciparum 3D7, a well-known chloroquine-sensitive strain. The present results provide a referential basis to support the traditional use of Eriosema species in the treatment of malaria.     

Application de l'approximation polytropique à la turbulence statistique en moyenne de FavreApplication of the polytropic approximation to turbulence statistics using Favre averaging

The application of the polytropic approximation connecting the quantities of corresponding state, to experimental analysis, is clarified. A method of polytropic determination of the exponent χ (variable but non-fluctuating) in each point of the flow is given. This approximation makes it possible the generation of representative signals of fluctuating quantities, like pressure or density. For heated gases, the problem of measurement of the equations terms written with Favre averaging is thus almost solved. Then, measurement of χ allows the determination by the experiment of crucial terms like turbulent fluxes of mass and momentum, and presso correlation. To cite this article: C. Rey, S. Benjeddou, C. R. Mecanique 332 (2004).     

An optimal control approach to the analysis of inelastic structures under cyclic loading

Optimal control theory is used to study the asymptotic behaviour of elasto-viscoplastic structures under cyclic loading. With this approach, the asymptotic state is found as the solution of a minimization problem. General properties of this method are established. A simple thermomechanical problem is studied to illustrate and validate this approach. An interest of the proposed method lies in its capacity to handle other nonlinearities than plasticity. To illustrate this point, the approach is extended to the coupled viscoplasticity/frictionless contact problem. Some numerical results are given for an elasto-viscoplastic half-plane under cyclic frictionless indentation.     

Application de l'approximation polytropique à la Simulation Numérique Directe de gaz chaudsApplication of the polytropique approximation to Direct Numerical Simulation of heated gases

As alternative to the usual assumptions of Boussinesq, we propose, for heated gases, a new approximation called polytropic approximation. With this approximation the quantities of corresponding state are related by a polytropic law of exponent χ of which we neglect the variability in space-time derivations in the equations governing the flow considered. As application, we used this new proposition to solve numerically a heated gas flow in an annular cavity of rotor-stator type. We expose here the numerical method and some results of the polytropic approximation with comparison to results of Boussinesq approximations. To cite this article: S. Benjeddou et al., C. R. Mecanique 332 (2003).     

Large Deviations from a Stationary Measure for a Class of Dissipative PDEs with Random Kicks

We study a class of dissipative PDEs perturbed by a bounded random kick force. It is assumed that the random force is nondegenerate, so that the Markov process obtained by the restriction of solutions to integer times has a unique stationary measure. The main result of the paper is a large deviations principle for occupation measures of the Markov process in question. The proof is based on Kifer's large‐deviation criterion, a coupling argument for Markov processes, and an abstract result on large‐time asymptotic for generalized Markov semigroups.© 2015 Wiley Periodicals, Inc.